Variables | Baseline | 12-week | 20-week | Interaction |
---|---|---|---|---|
Left Ventricle (LV) | ||||
LV septal wall thickness (mm) | 6.1 ± 1.1 | 6.6 ± 1.5 | 7.2 ± 1.4# | 0.027 |
LV posterior wall thickness (mm) | 5.5 ± 1.3 | 6.6 ± 1.4* | 7.1 ± 1.3## | < 0.001 |
RWT | 0.24 ± 0.05 | 0.28 ± 0.05* | 0.29 ± 0.06## | 0.007 |
3D LV mass (g) | 120.1 ± 15.4 | 132.9 ± 15.6* | 133.7 ± 16.3## | < 0.001 |
3D LV EDV (ml) | 146.4 ± 18.9 | 156.5 ± 20.8* | 157.9 ± 19.6## | < 0.001 |
3D LV ESV (ml) | 64 ± 10 | 69.4 ± 12.3* | 68.1 ± 11.8# | 0.003 |
3D LV ejection fraction (%) | 56.5 ± 3.3 | 55.9 ± 3.8 | 57 ± 4.5 | 0.789 |
LV GLS (%) | 20.7 ± 1.8 | 20.3 ± 1.6 | 20.4 ± 1.7 | 0.28 |
Peak Em (cm.s− 1) | 76.7 ± 10.4 | 77.6 ± 12.1 | 79.6 ± 10.9 | 0.557 |
Peak Am (cm.s− 1) | 44.5 ± 8.9 | 44 ± 8.2 | 43.9 ± 7.6 | 0.926 |
Em/Am ratio | 1.79 ± 0.47 | 1.83 ± 0.5 | 1.86 ± 0.39 | 0.770 |
averaged em’ (cm.s− 1) | 15.1 ± 1.9 | 15.4 ± 2.1 | 15.3 ± 2.6 | 0.575 |
Right Ventricle (RV) | ||||
RV wall thickness (mm) | 3.33 ± 0.73 | 3.76 ± 0.71 | 3.89 ± 0.8# | 0.014 |
3D RV EDV (ml) | 119 ± 19.4 | 126.7 ± 18.7* | 129.2 ± 21.6## | < 0.001 |
3D RV ESV (ml) | 53.9 ± 11.5 | 58.4 ± 13.3* | 58.2 ± 11.3## | 0.004 |
3D RV ejection fraction (%) | 54.7 ± 6 | 54.1 ± 5.4 | 54.9 ± 4.3 | 0.789 |
RV/LV EDV ratio | 0.81 ± 0.09 | 0.81 ± 0.08 | 0.82 ± 0.1 | 0.950 |
Peak RV S’ (cm.s− 1) | 13.5 ± 2.1 | 13.1 ± 2.1 | 13.2 ± 2.2 | 0.595 |
TAPSE (mm) | 22.5 ± 3.3 | 24.1 ± 3.5 | 24.9 ± 3.3 | 0.019 |
Peak Et (cm.s− 1) | 49.4 ± 7.3 | 51.4 ± 7.8 | 50.5 ± 6 | 0.582 |
Peak At (cm.s− 1) | 32.1 ± 4.7 | 30.7 ± 5.8 | 31.5 ± 8.3 | 0.761 |
Et/At ratio | 1.55 ± 0.23 | 1.71 ± 0.3 | 1.68 ± 0.38 | 0.353 |
Lateral e’t (cm.s− 1) | 12.4 ± 2.9 | 12.9 ± 2.8 | 13.2 ± 2.7 | 0.109 |
Atrial volumes | ||||
Left atrial volume (mL) | 33.2 ± 9.4 | 32.6 ± 7.6 | 32.1 ± 8.7 | 0.778 |
Right atrial volume (mL) | 31.3 ± 8.5 | 32.9 ± 8.3 | 33.1 ± 8.7 | 0.617 |